Online Advisory

Back Home
Contact us
Products Class
Contact us

Sincerity Enterprise Ltd

Contact: Ms Queenie
Tel: +86-571-89081561
Mobile: +86-13588232554
Fax: +86-571-89081566
Address: 16#Longtan Rd,cangqian town,Hangzhou,China
Product Current position:Home > Product> N,N-Dimethylformaide(DMF)
CAS No:   617-84-5
Usage:   for pharma use

The N,N-Diethylformamide, with the CAS registry number 617-84-5, is also known as Diethylformamide. It belongs to the product categories of Amides; Carbonyl Compounds; Organic Building Blocks. Its EINECS number is 210-533-2. This chemical's molecular formula is C5H11NO and molecular weight is 101.15. What's more, its systematic name is N,N-Diethylformamide. This chemical is stable at common pressure and temperature, and it should be sealed and stored in a cool, ventilated and dry place. This chemical is an industrial solvent claimed to have HIV protease inhibitory action. It is used as solvent, corrosion remover and vermifuge.

Physical properties of N,N-Diethylformamide are: (1)ACD/LogP: 0.19; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.19; (4)ACD/LogD (pH 7.4): 0.19; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 30.21; (8)ACD/KOC (pH 7.4): 30.21; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 20.31 Å2; (13)Index of Refraction: 1.418; (14)Molar Refractivity: 29.121 cm3; (15)Molar Volume: 115.641 cm3; (16)Polarizability: 11.545×10-24cm3; (17)Surface Tension: 27.8 dyne/cm; (18)Density: 0.875 g/cm3; (19)Flash Point: 69.109 °C; (20)Enthalpy of Vaporization: 41.38 kJ/mol; (21)Boiling Point: 177.499 °C at 760 mmHg; (22)Vapour Pressure: 1.0 mmHg at 25°C.

Preparation: this chemical can be prepared by diethylamine and formaldehyde at the ambient temperature. This reaction will need reagent KI and solvent H2O. The yield is about 85%.

N,N-Diethylformamide can be prepared by diethylamine and formaldehyde at the ambient temperature

Uses of N,N-Diethylformamide: it can be used to produce Diethyltrifluoromethylamine at the temperature of 150 °C. It will need reagents sulphur tetrafluoride, potassium fluoride with the reaction time of 48 hours. The yield is about 89.5%.

N,N-Diethylformamide can be used to produce Diethyltrifluoromethylamine at the temperature of 150 °C

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(2)Std. InChI: InChI=1S/C5H11NO/c1-3-6(4-2)5-7/h5H,3-4H2,1-2H3

The toxicity data is as follows:  


Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 3200mg/kg (3200mg/kg)   Therapie. Vol. 26, Pg. 409, 1971.
rat LD50 intraperitoneal 1740mg/kg (1740mg/kg)   Biochemical Journal. Vol. 85, Pg. 72, 1962.
rat LD50 unreported 1740mg/kg (1740mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 330, 1986.

Friend Links