Tetramethylammonium hydroxide, with the CAS registry number 75-59-2, is also known as TMAH. It belongs to the product categories of Quarternary Ammonium Bases; Ammonium Hydroxides (Quaternary); Ion Pair Reagents; Ion Pair Reagents - Anionic Concentrate. Its EINECS number is 200-882-9. This chemical's molecular formula is C4H13NO and molecular weight is 91.15. Its IUPAC name is called tetramethylammonium hydroxide.It is a colourless to yellow liquid with a strong ammonia-like odor which is stable,flammable,incompatible with strong oxidizing agents,strong acids.
Properties of Tetramethylammonium hydroxide:
(1)H-Bond Donor: 1; (2)H-Bond Acceptor: 1; (3)Rotatable Bond Count: 0; (4)Exact Mass: 91.099714; (5)MonoIsotopic Mass: 91.099714; (6)Topological Polar Surface Area: 1; (7)Heavy Atom Count: 6; (8)Formal Charge: 0; (9)Complexity: 19.1; (10)Isotope Atom Count: 0; (11)Defined Atom StereoCenter Count: 0; (12)Undefined Atom StereoCenter Count: 0; (13)Defined Bond StereoCenter Count: 0; (14)Undefined Bond StereoCenter Count: 0; (15)Covalently-Bonded Unit Count: 2.
Structure Descriptors of Tetramethylammonium hydroxide:
(1)Canonical SMILES: C[N+](C)(C)C.[OH-]
(2)InChI: InChI=1S/C4H12N.H2O/c1-5(2,3)4;/h1-4H3;1H2/q+1;/p-1
(3)InChIKey: WGTYBPLFGIVFAS-UHFFFAOYSA-M
Toxicity of Tetramethylammonium hydroxide is as follows :
|
Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
|
frog |
LDLo |
parenteral |
5mg/kg (5mg/kg) |
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION |
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 688, 1948. |
|
frog |
LDLo |
unreported |
1515ug/kg (1.515mg/kg) |
|
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 681, 1948. |
|
guinea pig |
LD50 |
skin |
25mg/kg (25mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
National Technical Information Service. Vol. OTS0570994, |
|
mouse |
LDLo |
subcutaneous |
19mg/kg (19mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 367, 1926. |
|
rabbit |
LDLo |
intravenous |
1mg/kg (1mg/kg) |
|
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 688, 1948. |
Use of Tetramethylammonium hydroxide
Tetramethylammonium hydroxide can be used to produce tetramethyl-ammonium; azide. This reaction will need reagent HN
3•H
2O and solvents CHCl
3, H
2O. The yield is about 60%.
Tetramethylammonium hydroxide is used as an anisotropic etchant of silicon. It is also used as a basic solvent in the development of acidic photoresist in the photolithography process. Since it is a phase transfer catalyst, it is highly effective in stripping photoresist. It is also used as a surfactant in the synthesis of ferrofluid, to prevent agglomeration.
Safety information of Tetramethylammonium hydroxide:
When you are using Tetramethylammonium hydroxide, please be cautious about it as the following:Tetramethylammonium hydroxide may destroy living tissue on contact and may cause burns. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
